Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642949 | 0.93 | HPGD (0.36) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL8129886 | 0.92 | GRIN2B (0.40) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL9518563 | 0.89 | CYP4F2 (0.32) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL2246036 | 0.87 | GRIN2B (0.43) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL15922454 | 0.86 | GRIN2B (0.39) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL14956788 | 0.79 | GRIN2B (0.38) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL705581 | 0.79 | GRIN2B (0.38) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL14956785 | 0.79 | GRIN2B (0.38) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL2981422 | 0.78 | JAK3 (0.48) | GRIN2BGRIN2CJAK3HPGDUSP2 | |
| SCHEMBL18561055 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |