Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CASP3 | P42574 | 2/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | LSS | P48449 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19719043 | 0.86 | CTSV (0.67) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL4058775 | 0.83 | HRH3 (0.65) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL6295064 | 0.83 | NPC1 (0.58) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL10514020 | 0.83 | CTSV (0.63) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL10514160 | 0.83 | CTSV (0.63) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL25455003 | 0.82 | TNKS (0.56) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL15223994 | 0.80 | CHEK2 (0.53) | TNKSPDGFRBPDGFRALSSACHE | |
| SCHEMBL12392527 | 0.77 | PDGFRB (0.52) | TNKSKDM4EPDGFRBPDGFRALSS | |
| SCHEMBL19719044 | 0.77 | RAB9A (0.64) | TNKSHRH3NPC1RAB9AKDM4E | |
| SCHEMBL4065305 | 0.77 | HRH3 (0.81) | HRH3NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872834-B2 | Phenyl-substituted indoles and indazoles | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-20020006928-A1 | Phenyl-substituted indoles and indazoles | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006928-A1 | Phenyl-substituted indoles and indazoles | IDO1, IDO2, AADAC | TNKS 84/4885HRH3 1173/4885NPC1 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.