SCHEMBL6300911

SCHEMBL6300911

Cc1c(Cl)ccc(Cl)c1C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.58
ALDH1A1 P00352 6/20 0.55
KDM4E B2RXH2 1/20 0.55
HSD17B10 Q99714 1/20 0.55
KMT2A Q03164 2/20 0.45
NOTUM Q6P988 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
CTSB P07858 1/20 0.43
CSNK2A2 P19784 1/20 0.42
CSNK2B P67870 1/20 0.42
CSNK2A1 P68400 1/20 0.42
DHODH Q02127 1/20 0.41
TSHR P16473 1/20 0.41
PDE10A Q9Y233 1/20 0.41
MAPK1 P28482 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 1/20 0.41
USP2 O75604 1/20 0.41
MT-CO2 P00403 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4638190 0.86 ALDH1A1 (0.52) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL2789527 0.85 DPP4 (0.52) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL11339108 0.85 DPP4 (0.57) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL31335850 0.85 DPP4 (0.52) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL27280575 0.85 DPP4 (0.52) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL29042676 0.85 DPP4 (0.47) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL23089488 0.83 DPP4 (0.50) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL7018050 0.83 DPP4 (0.45) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL22208791 0.83 DPP4 (0.45) DPP4ALDH1A1KDM4EHSD17B10KMT2A
SCHEMBL3706794 0.83 FABP3 (0.50) DPP4ALDH1A1KDM4EHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023004400-A1 DIBENZOXANTHENE QUENCHERS, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2023-01-26 WO disclosed
US-20220095612-A1 MICRONUTRIENT COMPOSITIONS AND SYSTEMS AND METHODS OF USING SAME NANOCHEM SOLUTIONS INC 2022-03-31 US disclosed
EP-3339303-B9 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2021-07-21 EP disclosed
EP-3339303-B9 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2021-07-21 EP disclosed
EP-3339303-B1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2020-06-24 EP disclosed
EP-3339303-B1 ARYL AND HETEROARYL FUSED LACTAMS PFIZER (US) 2020-06-24 EP disclosed
US-10570121-B2 Substituted dihydroisoquinolinone compounds PFIZER INC. (US) 2020-02-25 US disclosed
EP-3521285-A1 SUBSTITUTED DIHYDROISOQUINOLINONE COMPOUNDS Pfizer Inc (US) 2019-08-07 EP disclosed
US-10266542-B2 EZH2 inhibitors Mirati Therapeutics, Inc. (US) 2019-04-23 US disclosed
US-10266542-B2 EZH2 inhibitors Mirati Therapeutics, Inc. (US) 2019-04-23 US disclosed
US-4055409-A Pyrazole plant growth regulants E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-10-25 US disclosed
US-4046798-A Herbicidal 4-trifluoromethyl-4'nitrodiphenyl ethers ROHM AND HAAS COMPANY (US) 1977-09-06 US disclosed
US-4039588-A ALKOXY, AMINO, HALO-, OR CYANO-SUBSTITUTED ROHM AND HAAS COMPANY (US) 1977-08-02 US disclosed
US-4038285-A BUFFER SOLUTIONS, PICRATE DYES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-07-26 US disclosed
US-4029687-A HERBICIDES CIBA-GEIGY AG (CH) 1977-06-14 US disclosed
US-4004914-A HERBICIDES CIBA-GEIGY AG (CH) 1977-01-25 US disclosed
US-3962307-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-06-08 US disclosed
US-3954875-A Benzophenone herbicides ROHM AND HAAS COMPANY (US) 1976-05-04 US disclosed
US-3950379-A HERBICIDES ROHM AND HAAS COMPANY (US) 1976-04-13 US disclosed
US-3948937-A Pyrazole plant growth regulants E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10570121-B2 Substituted dihydroisoquinolinone compounds H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KRAS, TP53 DPP4 3539/4885ALDH1A1 1180/4885KDM4E 1310/4885
US-10266542-B2 EZH2 inhibitors EZH2, BMI1, EED DPP4 1965/4885ALDH1A1 1969/4885KDM4E 27/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.