Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 9/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301068 | 0.87 | ADRB3 (0.45) | ADRB3ADRB2ADRB1VCPGAA | |
| SCHEMBL6074794 | 0.85 | ADRB3 (0.60) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL6309219 | 0.83 | ADRB1 (0.39) | ADRB3ADRB2ADRB1VCPSMN1; SMN2 | |
| SCHEMBL6308617 | 0.79 | MAPT (0.40) | ADRB3ADRB2ADRB1VCPNPC1 | |
| SCHEMBL6301062 | 0.75 | ADRB3 (0.55) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL6301103 | 0.75 | ADRB3 (0.55) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL6301064 | 0.74 | HRH3 (0.55) | — | |
| SCHEMBL6301065 | 0.74 | ADRB3 (0.61) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL6074461 | 0.70 | ADRB3 (0.61) | ADRB3ADRB2ADRB1MEN1CYP1A2 | |
| SCHEMBL6797304 | 0.70 | ADRB3 (0.67) | ADRB3ADRB2ADRB1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | disclosed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | disclosed |