Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 8/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300969 | 0.87 | ADRB3 (0.44) | ADRB3ADRB2ADRB1GAAVCP | |
| SCHEMBL6301065 | 0.86 | ADRB3 (0.61) | ADRB3ADRB2ADRB1CASR | |
| SCHEMBL6301116 | 0.83 | CASR (0.41) | ADRB3ADRB2ADRB1CASRKDM4E | |
| SCHEMBL6303593 | 0.80 | CASR (0.39) | ADRB3GAACASRKDM4EALDH1A1 | |
| SCHEMBL6074794 | 0.72 | ADRB3 (0.60) | ADRB3ADRB2ADRB1CASR | |
| SCHEMBL6804674 | 0.72 | ADRB3 (0.62) | ADRB3ADRB2ADRB1CASR | |
| SCHEMBL6301113 | 0.70 | ADRB3 (0.43) | ADRB3ADRB2ADRB1CASR | |
| SCHEMBL6309219 | 0.69 | ADRB1 (0.39) | ADRB3ADRB2ADRB1VCPKDM4E | |
| SCHEMBL6074461 | 0.69 | ADRB3 (0.61) | ADRB3ADRB2ADRB1 | |
| SCHEMBL6074252 | 0.69 | ADRB3 (0.61) | ADRB3ADRB2ADRB1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | disclosed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | disclosed |