Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 9/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303591 | 0.89 | ADRB3 (0.42) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL6309214 | 0.86 | MEN1 (0.46) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL6301116 | 0.85 | CASR (0.41) | ADRB3ADRB2ADRB1POLBHDAC3 | |
| SCHEMBL6301065 | 0.84 | ADRB3 (0.61) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL5210082 | 0.76 | ADRB3 (0.61) | ADRB3ADRB2ADRB1 | |
| SCHEMBL6307432 | 0.76 | HRH3 (0.48) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL6303671 | 0.76 | HRH3 (0.48) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL6308613 | 0.75 | MAPT (0.42) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL6303593 | 0.74 | CASR (0.39) | ADRB3KMT2APOLBCASRLMNA | |
| SCHEMBL6309219 | 0.72 | ADRB1 (0.39) | ADRB3ADRB2ADRB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | disclosed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | disclosed |