Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 8/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.38 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303593 | 0.89 | CASR (0.39) | CASRKDM4ECHRM2CHRM5CHRM3 | |
| SCHEMBL6309219 | 0.86 | ADRB1 (0.39) | KDM4ECHRM2CHRM5CHRM3ALDH1A1 | |
| SCHEMBL6301113 | 0.85 | ADRB3 (0.43) | CASRHDAC3HDAC1ADRB3ADRB2 | |
| SCHEMBL6301068 | 0.83 | ADRB3 (0.45) | CASRKDM4ECHRM2CHRM5CHRM3 | |
| SCHEMBL6308617 | 0.75 | MAPT (0.40) | ALDH1A1SMN1; SMN2ADRB3ADRB2ADRB1 | |
| SCHEMBL6303591 | 0.74 | ADRB3 (0.42) | CASRALDH1A1SMN1; SMN2ADRB3ADRB2 | |
| SCHEMBL6301416 | 0.72 | SMYD3 (0.54) | HDAC3HDAC1ALDH1A1SMN1; SMN2POLB | |
| Water SCHEMBL5211069 | 0.71 | SMYD3 (0.53) | HDAC3HDAC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6301065 | 0.70 | ADRB3 (0.61) | CASRADRB3ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL6139757 | 0.70 | SMYD3 (0.52) | HDAC3HDAC1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | disclosed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | disclosed |