Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GLI1 | P08151 | 1/20 | 0.32 |
| ▸ | GLI2 | P10070 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | WRN | Q14191 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302218 | 0.91 | ESR1 (0.36) | ESR1OPRK1LMNASMN1; SMN2OPRM1 | |
| SCHEMBL6302220 | 0.91 | ESR1 (0.36) | ESR1OPRK1LMNASMN1; SMN2OPRM1 | |
| SCHEMBL6301600 | 0.89 | KDM4E (0.34) | KDM4EGRIN2BESR1MEN1KMT2A | |
| SCHEMBL6297134 | 0.88 | GRIN2B (0.35) | KDM4EGRIN2BOPRK1LMNASMN1; SMN2 | |
| SCHEMBL6297241 | 0.87 | LMNA (0.34) | KDM4EGRIN2BESR1OPRK1LMNA | |
| SCHEMBL6297058 | 0.87 | LMNA (0.36) | KDM4EGRIN2BESR1MEN1KMT2A | |
| SCHEMBL6295490 | 0.86 | OPRD1 (0.35) | KDM4EGRIN2BESR1MEN1KMT2A | |
| SCHEMBL6295911 | 0.86 | KDM4E (0.32) | KDM4EGRIN2BOPRK1LMNASMN1; SMN2 | |
| SCHEMBL6295454 | 0.85 | ESR1 (0.36) | KDM4EGRIN2BESR1MEN1KMT2A | |
| SCHEMBL6295877 | 0.85 | GLI1 (0.34) | KDM4EGRIN2BESR1GLI1GLI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030171425-A1 | HIV protease inhibitors | BOYER FREDERICK EARL (US) | 2003-09-11 | — | — | US | claimed |
| US-6512006-B1 | Novel 3-position Nitrogen substituted 6,6- disubstituted-5, 6-dihydropyrones and related compounds possess antiviral properties | WARNER-LAMBERT COMPANY | 2003-01-28 | — | — | US | claimed |
| US-6927217-B2 | HIV protease inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-08-09 | — | — | US | disclosed |
| US-20030171425-A1 | HIV protease inhibitors | BOYER FREDERICK EARL (US) | 2003-09-11 | — | — | US | disclosed |
| US-6512006-B1 | Novel 3-position Nitrogen substituted 6,6- disubstituted-5, 6-dihydropyrones and related compounds possess antiviral properties | WARNER-LAMBERT COMPANY | 2003-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171425-A1 | HIV protease inhibitors | DNPEP, PRSS1, PREP | KDM4E 1481/4885GRIN2B 2591/4885ESR1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.