Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRD2 | P25440 | 2/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630055 | 0.94 | KCNQ1 (0.47) | POLBSMN1; SMN2MAPTKMT2AGAA | |
| SCHEMBL630495 | 0.94 | POLB (0.44) | EPHX2POLBBRD4BRD2BRD3 | |
| SCHEMBL631414 | 0.94 | POLB (0.42) | EPHX2POLBBRD4BRD2BRD3 | |
| SCHEMBL1380078 | 0.89 | POLB (0.53) | EPHX2POLBBRD4BRD2BRD3 | |
| SCHEMBL630103 | 0.89 | POLB (0.53) | EPHX2POLBBRD4BRD2BRD3 | |
| SCHEMBL630210 | 0.84 | KCNQ1 (0.54) | POLBMAPTGAALMNAALDH1A1 | |
| SCHEMBL1382352 | 0.84 | POLB (0.51) | POLBBRD4SMN1; SMN2MAPTKMT2A | |
| SCHEMBL631349 | 0.83 | POLB (0.54) | POLBSMN1; SMN2MAPTKMT2AGAA | |
| SCHEMBL1381295 | 0.83 | POLB (0.54) | POLBSMN1; SMN2MAPTKMT2AGAA | |
| SCHEMBL630024 | 0.83 | POLB (0.54) | POLBSMN1; SMN2MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |