Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 8/20 | 0.36 |
| ▸ | PRKCA | P17252 | 7/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.36 |
| ▸ | PRKCG | P05129 | 5/20 | 0.36 |
| ▸ | PRKCH | P24723 | 5/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303465 | 0.90 | CHRNA7 (0.52) | CHRNA7EZH2CYP3A4 | |
| SCHEMBL6305921 | 0.89 | HPGD (0.46) | CHRNA7EZH2CYP3A4HTTPANK3 | |
| SCHEMBL6305281 | 0.89 | DDB1 (0.43) | CHRNA7EZH2CYP3A4HTTPANK3 | |
| SCHEMBL6310174 | 0.89 | TRPV1 (0.44) | CHRNA7EZH2GRM2GRM3TRPV1 | |
| SCHEMBL6305910 | 0.89 | CHRNA7 (0.40) | CHRNA7EZH2CYP3A4HTTPANK3 | |
| SCHEMBL6303188 | 0.89 | CHRNA7 (0.42) | CHRNA7EZH2PRKCBPRKCAPRKCE | |
| SCHEMBL6305491 | 0.86 | CNR2 (0.43) | CHRNA7EZH2CNR2GRM2GRM3 | |
| SCHEMBL6303219 | 0.85 | MMP2 (0.43) | EZH2CNR2PRKCBPRKCAPRKCE | |
| SCHEMBL6304940 | 0.85 | CHRNA7 (0.40) | CHRNA7EZH2HTTPANK3 | |
| SCHEMBL6303176 | 0.85 | CHRNA7 (0.40) | CHRNA7EZH2PRKCBPRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
| US-6852716-B2 | Substituted-aryl compounds for treatment of disease | PFIZER INC (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | NAT1, CYP7A1, CYP7B1 | CHRNA7 2937/4885EZH2 4701/4885CNR2 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.