SCHEMBL6304232

SCHEMBL6304232

Cc1csc(S(=O)(=O)c2nc3cc(Cl)c(Cl)cc3nc2C(C)C)n1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GLP1R P43220 18/20 0.66
TXNRD1 Q16881 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6304109 0.80 GLP1R (1.00) GLP1R
SCHEMBL6311397 0.78 GLP1R (0.60) GLP1RTXNRD1
SCHEMBL6307427 0.74 GLP1R (1.00) GLP1R
SCHEMBL6310949 0.73 GLP1R (0.73) GLP1R
SCHEMBL6307037 0.69 GLP1R (0.42) GLP1R
SCHEMBL6311039 0.68 GLP1R (0.57) GLP1R
SCHEMBL6306880 0.66 GLP1R (0.53) GLP1R
SCHEMBL6311010 0.66 GLP1R (0.77) GLP1R
SCHEMBL6305823 0.63 GLP1R (0.58) GLP1R
SCHEMBL212986 0.63 SMN1; SMN2 (0.41) TXNRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6927214-B1 Non-peptide GLP-1 agonists NOVO NORDISK A/S (DK) 2005-08-09 US disclosed
EP-1147094-A1 NON-PEPTIDE GLP-1 AGONISTS NOVO NORDISK A/S (DK) 2001-10-24 EP disclosed
WO-2000042026-A1 NON-PEPTIDE GLP-1 AGONISTS NOVO NORDISK A/S (DK) 2000-07-20 WO disclosed