Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | KHK | P50053 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22963739 | 0.91 | HTT (0.65) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL29396650 | 0.91 | HTT (0.65) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL6304076 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL6088752 | 0.83 | ALDH1A1 (1.00) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL22912779 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL29396732 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL30908290 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL10211596 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL6307894 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1HTTLMNAKHK | |
| SCHEMBL22963740 | 0.79 | HTT (0.59) | KDM4EALDH1A1HTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927214-B1 | Non-peptide GLP-1 agonists | NOVO NORDISK A/S (DK) | 2005-08-09 | — | — | US | disclosed |
| EP-1147094-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042026-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-20 | — | — | WO | disclosed |