Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.64 |
| ▸ | KDM1A | O60341 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 5/20 | 0.52 |
| ▸ | MAOB | P27338 | 5/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20856195 | 0.91 | GID4 (0.66) | GID4KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL28603159 | 0.85 | KDM1A (0.55) | GID4KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL6306064 | 0.85 | GID4 (0.68) | GID4KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL28596328 | 0.82 | GID4 (0.59) | GID4KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL28596345 | 0.79 | GID4 (0.56) | GID4KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL20863607 | 0.79 | GID4 (1.00) | GID4KDM1AMAOAMAOB | |
| SCHEMBL17274560 | 0.78 | HTR2A (0.47) | KDM1AMAOAMAOBSLC6A2SLC6A4 | |
| SCHEMBL6300145 | 0.78 | DDB1 (0.46) | GID4KDM1AMAOAMAOBCYP19A1 | |
| SCHEMBL17274561 | 0.78 | HTR2A (0.47) | KDM1AMAOAMAOBSLC6A2SLC6A4 | |
| SCHEMBL17274558 | 0.78 | HTR2A (0.47) | KDM1AMAOAMAOBSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794308-B | 1,2,3, 4-tetrahydronaphthalene compound and preparation method and application thereof | 北京大学深圳研究生院 | 2021-07-20 | — | — | CN | disclosed |
| US-6943183-B2 | 5-substituted tetralones as inhibitors of ras farnesyl transferase | PFIZER INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | WARNER-LAMBERT COMPANY | 2004-03-04 | — | — | US | disclosed |
| EP-1276725-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001079180-A2 | 5-SUBSTITUTED TETRALONES AS INHIBITORS OF RAS FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | PTAR1, FNTA, GGPS1 | GID4 1034/4885KDM1A 3120/4885MAOA 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.