Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.53 |
| ▸ | POLA1 | P09884 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309964 | 1.00 | NR1H2 (0.53) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6310209 | 0.85 | CYP3A4 (0.71) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6310212 | 0.85 | CYP3A4 (0.71) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6312187 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6312190 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL20561120 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6310832 | 0.84 | NR1H2 (0.53) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6309929 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL6309935 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR | |
| SCHEMBL29295291 | 0.84 | POLA1 (0.72) | NR1H2NR1H3POLA1CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908934-B2 | Therapeutic compounds for treating dyslipidemic conditions | MERCK & CO., INC. (US) | 2005-06-21 | — | — | US | disclosed |
| US-20030125357-A1 | Therapeutic compounds for treating dyslipidemic conditions | MERCK & CO., INC. | 2003-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125357-A1 | Therapeutic compounds for treating dyslipidemic conditions | NR1H2, NR1H3, APOB | NR1H2 1/4885NR1H3 2/4885POLA1 3183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.