Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.71 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | PTPRC | P08575 | 1/20 | 0.67 |
| ▸ | PTPRF | P10586 | 1/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.67 |
| ▸ | PTPA | Q15257 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27558689 | 0.91 | GSTO1 (0.63) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11634946 | 0.88 | LMNA (0.74) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23580345 | 0.86 | LMNA (0.73) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9396589 | 0.85 | LMNA (0.79) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23599197 | 0.85 | LMNA (0.74) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2981645 | 0.84 | LMNA (0.79) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5804336 | 0.84 | POLB (0.74) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5804332 | 0.84 | POLB (0.74) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2897094 | 0.84 | POLB (0.74) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23579845 | 0.83 | POLB (0.72) | LMNAGSTO1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | disclosed |
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2002-11-07 | — | — | US | disclosed |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | US | disclosed |
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| EP-1062204-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046244-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPRO | LMNA 4790/4885GSTO1 4077/4885SMN1; SMN2 1660/4885 |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | PTPRCAP, PTPRS, PTPRA | LMNA 4783/4885GSTO1 4079/4885SMN1; SMN2 1576/4885 |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPN1 | LMNA 4870/4885GSTO1 2855/4885SMN1; SMN2 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.