Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 11/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313007 | 0.80 | MEN1 (0.43) | MEN1KMT2AHTR2CGABRA1GABRG2 | |
| SCHEMBL8591946 | 0.80 | MEN1 (0.43) | MEN1KMT2AHTR2CGABRA1GABRG2 | |
| SCHEMBL6309715 | 0.75 | CYP2D6 (0.39) | MEN1KMT2AHTR2CGABRA1GABRG2 | |
| SCHEMBL9591123 | 0.74 | GPR3 (0.35) | HTR1AHTR2A | |
| SCHEMBL736013 | 0.72 | OPRL1 (0.50) | — | |
| SCHEMBL5758789 | 0.71 | HTR2C (0.49) | MEN1KMT2AHTR2CSLC18A3SIGMAR1 | |
| Dibenzothiophene SCHEMBL28254130 | 0.69 | GPR3 (0.70) | MEN1KMT2AHTR2C | |
| SCHEMBL28511836 | 0.69 | GPR3 (0.44) | MEN1KMT2AGABRA1GABRG2GABRB3 | |
| SCHEMBL4676658 | 0.68 | SLC6A4 (0.55) | MEN1KMT2AHTR2CSLC18A3SIGMAR1 | |
| SCHEMBL29868908 | 0.68 | SLC6A4 (0.55) | MEN1KMT2AHTR2CSLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844344-B2 | Benzofuran derivatives | ELI LILLY AND COMPANY (US) | 2005-01-18 | — | — | US | disclosed |
| US-20030232833-A1 | Benzofuran derivatives | ELI LILLY AND COMPANY | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232833-A1 | Benzofuran derivatives | BRD1, BPTF, HTR1F | MEN1 4207/4885KMT2A 781/4885HTR2C 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.