Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 18/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 18/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | PDXK | O00764 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312659 | 0.92 | FGFR1 (0.52) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| SCHEMBL6313429 | 0.88 | NR4A3 (0.56) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| SCHEMBL4454442 | 0.83 | FGFR1 (0.42) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| SCHEMBL4454445 | 0.82 | SLC9A1 (0.44) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| Hydrochloric Acid SCHEMBL6320000 | 0.82 | FGFR1 (0.42) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| SCHEMBL6315637 | 0.82 | NR4A3 (0.43) | FGFR1FGFR2FGFR3KDM4EMAPT | |
| SCHEMBL6320056 | 0.82 | NR4A3 (0.43) | FGFR1FGFR2FGFR3KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6320007 | 0.82 | SLC9A1 (0.43) | FGFR1FGFR2FGFR3SRCFGFR4 | |
| SCHEMBL6321499 | 0.81 | KMT2A (0.46) | KDM4EMAPTALOX15TSHRNR4A3 | |
| SCHEMBL6313435 | 0.79 | NR4A3 (0.56) | FGFR1FGFR2FGFR3SRCFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974813-B2 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | WARNER-LAMBERT COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER INC. | 2003-08-07 | — | — | US | disclosed |
| US-6492401-B1 | SODIUM HYDROGEN EXCHANGER TYPE 1 INHIBITORS; REDUCING PERIOPERATIVE MYOCARDIAL TISSUE DAMAGE | PFIZER, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | NHERF1, SLC28A1, TNNI3 | FGFR1 2482/4885FGFR2 4370/4885FGFR3 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.