Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370672 | 0.84 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL29582472 | 0.84 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL29359016 | 0.81 | LMNA (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL27926709 | 0.81 | LMNA (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL6312703 | 0.81 | SCN4A (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL19597584 | 0.76 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL28219649 | 0.76 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL31375650 | 0.74 | MCHR1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL31610805 | 0.74 | MCHR1 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL4728794 | 0.74 | KDM4E (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014810-A1 | Use of substituted 2 phenylbenzimidazoles as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014810-A1 | Use of substituted 2 phenylbenzimidazoles as medicaments | GLP1R, GIPR, GCGR | NPC1 2833/4885RAB9A 4571/4885SMN1; SMN2 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.