Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926709 | 1.00 | LMNA (0.55) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL19597584 | 0.84 | NPC1 (0.42) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL370672 | 0.84 | NPC1 (0.44) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL29582472 | 0.84 | NPC1 (0.44) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL10532918 | 0.81 | NPC1 (0.40) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6312703 | 0.81 | SCN4A (0.47) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6312698 | 0.81 | NPC1 (0.42) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL15835902 | 0.80 | NPC1 (0.43) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL28341249 | 0.80 | GRM2 (0.45) | LMNANPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6491400 | 0.79 | CYP1A2 (0.50) | LMNANPC1RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |