Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.77 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.63 |
| ▸ | CLK2 | P49760 | 2/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.63 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.63 |
| ▸ | MAOB | P27338 | 2/20 | 0.60 |
| ▸ | PRKX | P51817 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15147870 | 0.87 | ROCK2 (1.00) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL1664461 | 0.86 | NPC1 (1.00) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL12059650 | 0.86 | ROCK2 (0.79) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL5414918 | 0.83 | NPC1 (0.85) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL4112657 | 0.82 | ROCK2 (0.67) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL23430082 | 0.81 | NPC1 (0.65) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL1163706 | 0.80 | ROCK2 (0.74) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL26715360 | 0.80 | NPC1 (0.63) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL5643476 | 0.80 | ROCK2 (0.83) | ROCK1ROCK2NPC1RAB9ARPS6KB1 | |
| SCHEMBL20661268 | 0.79 | NPC1 (0.62) | ROCK1ROCK2NPC1RAB9ARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119304-A1 | Urea derivatives | BAYER HEALTHCARE AG (DE) | 2005-06-02 | — | — | US | claimed |
| US-20050119304-A1 | Urea derivatives | BAYER HEALTHCARE AG (DE) | 2005-06-02 | — | — | US | disclosed |
| EP-1465623-A1 | UREA DERIVATIVES | Bayer HealthCare AG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003055484-A1 | UREA DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119304-A1 | Urea derivatives | SLC14A1, UBA1, UFM1 | ROCK1 1838/4885ROCK2 4108/4885NPC1 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.