Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | ITGAL | P20701 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312245 | 0.86 | ITGB2 (0.42) | ITGB2ICAM1ITGALPTGER3PTGER2 | |
| SCHEMBL6310544 | 0.85 | KDM4E (0.34) | ITGB2ICAM1ITGALMAOBALDH1A1 | |
| SCHEMBL6316872 | 0.80 | ITGB2 (0.38) | ITGB2ICAM1ITGALPTGER3PTGER2 | |
| SCHEMBL6198648 | 0.74 | ITGB2 (0.47) | ITGB2ICAM1ITGALPTGER3PTGER2 | |
| SCHEMBL6312964 | 0.71 | ITGB2 (0.52) | ITGB2ICAM1ITGALPTGER3PTGER2 | |
| SCHEMBL7857946 | 0.69 | ITGB2 (0.45) | ITGB2ICAM1ITGALMAOBAKR1C3 | |
| SCHEMBL6199614 | 0.69 | ITGB2 (0.45) | ITGB2ICAM1ITGALMAOBAKR1C3 | |
| SCHEMBL6198651 | 0.68 | ITGB2 (0.69) | ITGB2ICAM1ITGALHDAC3TNKS | |
| SCHEMBL6198643 | 0.68 | ITGB2 (0.69) | ITGB2ICAM1ITGALHDAC3TNKS | |
| SCHEMBL11833309 | 0.64 | HDAC2 (0.58) | MAOBHDAC3TNKSHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |