Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385593 | 0.81 | HPGDS (0.63) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL29176103 | 0.79 | HPGDS (0.61) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL27462202 | 0.79 | HPGDS (0.61) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL4584140 | 0.77 | HPGDS (0.59) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL1176942 | 0.77 | HPGDS (0.59) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL10592999 | 0.77 | HPGDS (0.59) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL158020 | 0.77 | HPGDS (1.00) | HPGDSRAB9ADAOCYP2C9NPC1 | |
| SCHEMBL9412769 | 0.77 | HPGDS (0.59) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| SCHEMBL14947051 | 0.76 | CES2 (0.75) | HPGDSRAB9ADAOCYP1A2CYP3A4 | |
| Water SCHEMBL28007578 | 0.76 | HPGDS (0.96) | HPGDSRAB9ADAOCYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924301-B1 | Composition for treating or preventing arrhythmia | SHIONOGI & CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| EP-1240906-A1 | PREVENTIVES OR REMEDIES FOR ARRHYTHMIA | SHIONOGI & CO., LTD. (JP) | 2002-09-18 | — | — | EP | disclosed |
| EP-0615751-A1 | Use of tachykinin antagonists in the treatment of emesis | GLAXO GROUP LIMITED (GB) | 1994-09-21 | — | — | EP | disclosed |