Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.68 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30278513 | 0.81 | GRM5 (0.68) | GRM5ACACBPDE10AHAO1FBP1 | |
| SCHEMBL4747174 | 0.81 | GRM5 (0.68) | GRM5ACACBPDE10AHAO1FBP1 | |
| SCHEMBL6311975 | 0.81 | GRM5 (1.00) | GRM5ACACBPDE10AHAO1 | |
| SCHEMBL15870993 | 0.79 | GRM5 (0.68) | GRM5ACACBPDE10AHAO1FBP1 | |
| SCHEMBL702812 | 0.77 | GRM5 (0.62) | GRM5ACACBPDE10AHAO1FBP1 | |
| SCHEMBL10236313 | 0.77 | GRM5 (0.62) | GRM5ACACBPDE10AHAO1 | |
| SCHEMBL7717366 | 0.72 | GRM5 (0.50) | GRM5HAO1TP53 | |
| SCHEMBL718949 | 0.72 | GRM5 (0.50) | GRM5HAO1TP53 | |
| SCHEMBL10300106 | 0.72 | GRM5 (0.50) | GRM5HAO1TP53 | |
| SCHEMBL30278516 | 0.72 | GRM5 (0.47) | GRM5ACACBPDE10AHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |