⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507835 | 0.74 | KDM4E (0.31) | — | |
| SCHEMBL11290667 | 0.73 | CYP1A2 (0.34) | — | |
| SCHEMBL19571210 | 0.72 | ALDH1A1 (0.42) | — | |
| SCHEMBL19987623 | 0.72 | ALDH1A1 (0.42) | — | |
| SCHEMBL1159862 | 0.72 | ALDH1A1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL28585818 | 0.70 | ALDH1A1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL31519012 | 0.69 | BCL2 (0.33) | — | |
| SCHEMBL11715962 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL1445976 | 0.69 | — | — | |
| SCHEMBL7355037 | 0.68 | CYP1A2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257305-B1 | STABILIZATION OF IMPLANTABLE BIOPROSTHETIC TISSUE | PHILADELPHIA CHILDREN HOSPITAL (US) | 2005-08-24 | — | — | EP | disclosed |
| US-6824970-B2 | REDUCED POST- IMPLANTATION CALCIFICATION | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 2004-11-30 | — | — | US | disclosed |
| US-20020172706-A1 | Stabilization of implantable bioprosthetic tissue | CHILDREN'S HOSPITAL OF PHILADELPHIA | 2002-11-21 | — | — | US | disclosed |
| EP-1257305-A1 | STABILIZATION OF IMPLANTABLE BIOPROSTHETIC TISSUE | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6391538-B1 | HAS PROTEINS CROSSLINKED WITH POLY-(2-HYDROXYORGANO)AMINO MOIETY; REDUCED CALCIFICATION | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 2002-05-21 | — | — | US | disclosed |
| WO-2001058503-A1 | STABILIZATION OF IMPLANTABLE BIOPROSTHETIC TISSUE | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2001-08-16 | — | — | WO | disclosed |