Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321379 | 0.78 | PTGS1 (0.40) | PTGS1PTGS2EZH2MEN1KMT2A | |
| SCHEMBL6313350 | 0.73 | PTGS1 (0.36) | PTGS1PTGS2EZH2MEN1KMT2A | |
| SCHEMBL6314822 | 0.71 | PTGS1 (0.35) | PTGS1PTGS2 | |
| SCHEMBL6130770 | 0.66 | ALDH1A1 (0.38) | PTGS1PTGS2 | |
| SCHEMBL20127238 | 0.64 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL8713990 | 0.63 | KMT2A (0.41) | PTGS1PTGS2EZH2MEN1KMT2A | |
| SCHEMBL658987 | 0.62 | ALDH1A1 (0.42) | EZH2MEN1KMT2A | |
| SCHEMBL9571649 | 0.61 | MEN1 (0.33) | EZH2MEN1KMT2A | |
| SCHEMBL5775188 | 0.61 | CYP1A2 (0.36) | PTGS1PTGS2 | |
| SCHEMBL682824 | 0.60 | ALDH1A1 (0.39) | PTGS1PTGS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |