Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659226 | 0.80 | DHFR (0.39) | DHFRHTR2A | |
| SCHEMBL6321379 | 0.75 | PTGS1 (0.40) | PTGS1PTGS2 | |
| SCHEMBL20127238 | 0.73 | PTGS1 (0.33) | PTGS1PTGS2 | |
| SCHEMBL6130770 | 0.72 | ALDH1A1 (0.38) | PTGS1PTGS2 | |
| SCHEMBL6313856 | 0.71 | PTGS1 (0.32) | PTGS1PTGS2 | |
| SCHEMBL6313350 | 0.70 | PTGS1 (0.36) | PTGS1PTGS2 | |
| SCHEMBL682824 | 0.69 | ALDH1A1 (0.39) | PTGS1PTGS2 | |
| SCHEMBL12733214 | 0.68 | — | — | |
| SCHEMBL8877823 | 0.67 | ALDH1A1 (0.36) | DHFR | |
| SCHEMBL658195 | 0.67 | ALDH1A1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |