Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.59 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820213 | 0.84 | NR3C1 (0.68) | NR3C1PGRP2RX7SMN1; SMN2L3MBTL1 | |
| SCHEMBL6314576 | 0.84 | NR3C1 (0.65) | NR3C1PGRP2RX7SMN1; SMN2L3MBTL1 | |
| SCHEMBL5205603 | 0.81 | NR3C1 (0.66) | NR3C1PGRP2RX7 | |
| SCHEMBL1261042 | 0.75 | NR3C1 (0.32) | NR3C1PGR | |
| SCHEMBL809123 | 0.74 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL2143635 | 0.73 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL4820195 | 0.72 | NR3C1 (0.69) | NR3C1PGR | |
| SCHEMBL6314570 | 0.72 | NR3C1 (0.53) | NR3C1PGRP2RX7SMN1; SMN2L3MBTL1 | |
| SCHEMBL4818295 | 0.71 | NR3C1 (0.58) | NR3C1PGR | |
| SCHEMBL14269129 | 0.71 | NR3C1 (0.60) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897224-B2 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2005-05-24 | — | — | US | disclosed |
| US-20040116694-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2004-06-17 | — | — | US | disclosed |