Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314574 | 0.72 | NR3C1 (0.59) | NR3C1PGRALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4820213 | 0.71 | NR3C1 (0.68) | NR3C1PGRSMN1; SMN2L3MBTL1P2RX7 | |
| SCHEMBL6314576 | 0.71 | NR3C1 (0.65) | NR3C1PGRSMN1; SMN2L3MBTL1P2RX7 | |
| SCHEMBL809123 | 0.69 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL5205603 | 0.69 | NR3C1 (0.66) | NR3C1PGRP2RX7CRHR1 | |
| SCHEMBL2143635 | 0.68 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL3649830 | 0.67 | NR3C1 (0.69) | NR3C1PGRMEN1KMT2ACRHR1 | |
| SCHEMBL6320917 | 0.66 | NR3C1 (0.45) | NR3C1PGRALDH1A1 | |
| SCHEMBL821997 | 0.66 | NR3C1 (0.56) | NR3C1PGRSMN1; SMN2TRPV1MEN1 | |
| SCHEMBL4195130 | 0.64 | NR3C1 (1.00) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897224-B2 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2005-05-24 | — | — | US | disclosed |
| US-20040116694-A1 | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors | SCHERING AG (DE) | 2004-06-17 | — | — | US | disclosed |