Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.52 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18737418 | 0.84 | ALDH1A1 (0.62) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL18072576 | 0.79 | HTT (0.44) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL13263387 | 0.79 | ALOX15 (0.73) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL9464262 | 0.77 | MAPT (0.48) | ALDH1A1ALOX15CYP1A2KDM4EMAPT | |
| SCHEMBL30903400 | 0.77 | MAPT (0.48) | ALDH1A1ALOX15CYP1A2KDM4EMAPT | |
| SCHEMBL395984 | 0.77 | ALOX15 (0.70) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL29872633 | 0.77 | ALOX15 (0.70) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL5470246 | 0.74 | ALOX15 (0.75) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL824520 | 0.74 | ALOX15 (0.67) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL29395805 | 0.74 | ALOX15 (0.67) | ALDH1A1ALOX15SMN1; SMN2CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-4237326-A | SOLUTION OF METHYLATED BENZOQUINONE-4-OXIME | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1980-12-02 | — | — | US | disclosed |