Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6634000 | 0.92 | RORC (0.46) | RORCKCNK3KCNK9OPRD1OPRK1 | |
| SCHEMBL20722455 | 0.88 | RORC (0.47) | RORCKCNK3KCNK9OPRD1OPRK1 | |
| SCHEMBL6622717 | 0.85 | OPRD1 (0.44) | RORCKCNK3KCNK9OPRD1OPRK1 | |
| SCHEMBL29597428 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1GPR119JAK2 | |
| SCHEMBL18668633 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1GPR119JAK2 | |
| SCHEMBL24276430 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1GPR119JAK2 | |
| SCHEMBL18668635 | 0.84 | RORC (0.46) | RORCOPRD1OPRK1GPR119JAK2 | |
| SCHEMBL649847 | 0.84 | KCNK3 (0.55) | RORCKCNK3KCNK9OPRD1OPRK1 | |
| SCHEMBL16053284 | 0.84 | KCNK3 (0.55) | RORCKCNK3KCNK9OPRD1OPRK1 | |
| SCHEMBL584450 | 0.84 | KCNK3 (0.55) | RORCKCNK3KCNK9OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1192154-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076999-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |