Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617642 | 0.91 | ALDH1A1 (0.48) | EPHX2CYP2C9CYP2C19HPGDLMNA | |
| SCHEMBL6315451 | 0.87 | ALDH1A1 (0.47) | EPHX2CYP2C9CYP2C19HPGDLMNA | |
| SCHEMBL6315431 | 0.85 | ALDH1A1 (0.55) | EPHX2ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL6323619 | 0.83 | L3MBTL1 (0.62) | EPHX2ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL6316553 | 0.83 | ALDH1A1 (0.66) | LMNAALDH1A1L3MBTL1KDM4ECA1 | |
| SCHEMBL6316689 | 0.83 | ALDH1A1 (0.47) | LMNAALDH1A1L3MBTL1KDM4ECA1 | |
| SCHEMBL6317724 | 0.82 | L3MBTL1 (0.58) | EPHX2ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL6318002 | 0.82 | GAA (0.50) | ALDH1A1L3MBTL1KDM4EKMT2A | |
| SCHEMBL6323447 | 0.81 | EPHX2 (0.45) | EPHX2CYP2C9CYP2C19HPGDLMNA | |
| SCHEMBL6318188 | 0.81 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1KDM4ECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | EPHX2 4156/4885CYP2C9 4466/4885CYP2C19 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.