SCHEMBL6315569

SCHEMBL6315569

Nc1ccc(NC(=O)c2ccc(N)cc2O)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 3/20 0.77
SNCA P37840 1/20 0.60
PNLIP P16233 1/20 0.56
MAPT P10636 3/20 0.56
GAA P10253 2/20 0.56
POLB P06746 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
KDM4E B2RXH2 2/20 0.56
MEN1 O00255 1/20 0.56
LMNA P02545 1/20 0.56
PKM P14618 1/20 0.56
APEX1 P27695 1/20 0.56
KMT2A Q03164 1/20 0.56
ALDH1A1 P00352 1/20 0.56
CYP3A4 P08684 1/20 0.56
ESR2 Q92731 1/20 0.56
PTPN1 P18031 1/20 0.56
PLG P00747 6/20 0.54
KLK1 P06870 4/20 0.54
KLK6 Q92876 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2714581 0.90 KLKB1 (0.69) KLKB1SNCAPNLIPMAPTGAA
SCHEMBL9323417 0.88 SNCA (0.69) KLKB1SNCAMAPTPOLBTDP1
SCHEMBL5383984 0.86 KLKB1 (0.66) KLKB1PNLIPMAPTGAAPOLB
SCHEMBL17774881 0.86 P2RX1 (0.60) KLKB1SNCAMAPTPOLBTDP1
SCHEMBL9321111 0.84 SNCA (0.63) KLKB1SNCAMAPTPOLBTDP1
SCHEMBL9321026 0.84 SNCA (0.63) KLKB1SNCAMAPTPOLBTDP1
SCHEMBL6810850 0.82 LMNA (0.74) PNLIPMAPTGAAPOLBKDM4E
SCHEMBL19919334 0.82 KLKB1 (0.59) KLKB1PNLIPMAPTGAAPOLB
SCHEMBL2719747 0.82 KLKB1 (0.70) KLKB1POLBPLGKLK1KLK6
SCHEMBL9321085 0.81 KLKB1 (0.65) KLKB1SNCAPOLBTDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7207023-A None JP disclosed
JP-7149898-A None JP disclosed
US-20050181223-A1 Flexible metal foil-polyimide laminate and making method SHIN-ETSU CHEMICAL CO., LTD. 2005-08-18 US disclosed
WO-1998024776-A1 PREPARATION OF AN AMINOARYLAMINOARAZOLE THE DOW CHEMICAL COMPANY (US) 1998-06-11 WO disclosed
US-5739344-A Preparation of an aminoarylaminoarazole THE DOW CHEMICAL COMPANY (US) 1998-04-14 US disclosed
JP-H07207023-A POLYIMIDE COPOLYMER AND ITS PRODUCTION SHIN ETSU CHEM CO LTD 1995-08-08 JP disclosed
JP-H07149898-A PRODUCTION OF POLYAMIC ACID AND PRODUCTION OF POLYIMIDE SHIN ETSU CHEM CO LTD 1995-06-13 JP disclosed