Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954181 | 0.86 | TAAR1 (0.56) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13387367 | 0.81 | ALDH1A1 (0.46) | TAAR1KDM4EALDH1A1USP2AR | |
| SCHEMBL1039728 | 0.81 | AR (0.54) | KDM4EALDH1A1USP2AR | |
| SCHEMBL3677762 | 0.80 | TAAR1 (0.52) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8269049 | 0.80 | TAAR1 (0.52) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14566650 | 0.80 | TAAR1 (0.44) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12330214 | 0.77 | TAAR1 (0.48) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL957051 | 0.77 | MAPT (0.47) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12326171 | 0.76 | TAAR1 (0.48) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14507701 | 0.76 | TAAR1 (0.48) | TAAR1MAPTSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |
| CN-1024659-C | Phenol derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-05-25 | — | — | CN | disclosed |
| CN-1032001-A | The manufacturing of phenol derivatives and application | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1989-03-29 | — | — | CN | disclosed |