Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324844 | 0.89 | GAA (0.51) | GAAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL6319658 | 0.89 | GAA (0.54) | GAAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL6318216 | 0.83 | GAA (0.45) | GAAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL28612690 | 0.79 | GAA (0.62) | GAAMEN1TSHRKMT2AFUCA1 | |
| SCHEMBL28349386 | 0.79 | GAA (0.62) | GAAMEN1TSHRKMT2AFUCA1 | |
| SCHEMBL10990414 | 0.79 | GAA (0.67) | GAAMEN1TSHRKMT2AFUCA1 | |
| SCHEMBL12358688 | 0.77 | FUCA1 (0.50) | GAAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL19463297 | 0.76 | GAA (0.59) | GAAMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL14372131 | 0.76 | GAA (0.59) | GAAMEN1TSHRKMT2AFUCA1 | |
| SCHEMBL19463296 | 0.76 | GAA (0.59) | GAAMEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1192154-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076999-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |