Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316162 | 0.89 | GAA (0.57) | GAAKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL6318216 | 0.84 | GAA (0.45) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL20397168 | 0.81 | GAA (0.46) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL6319658 | 0.79 | GAA (0.54) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL20399590 | 0.79 | DRD4 (0.44) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL20399589 | 0.79 | DRD4 (0.44) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL29937252 | 0.73 | GAA (0.47) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL29937256 | 0.73 | GAA (0.47) | GAAKMT2AMEN1TSHRCYP2D6 | |
| SCHEMBL2381838 | 0.72 | CYP2D6 (0.67) | KMT2AMEN1TSHRCYP2D6ALDH1A1 | |
| SCHEMBL6318884 | 0.71 | S1PR5 (0.48) | GAAKMT2AMEN1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |