Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316162 | 0.89 | GAA (0.57) | GAATSHRMEN1KMT2AFUCA1 | |
| SCHEMBL29598556 | 0.82 | GAA (0.61) | GAATSHRMEN1KMT2ASIGMAR1 | |
| SCHEMBL6324844 | 0.79 | GAA (0.51) | GAATSHRMEN1KMT2AFUCA1 | |
| SCHEMBL23186699 | 0.78 | GAA (0.49) | GAATSHRMEN1KMT2AFUCA1 | |
| SCHEMBL14016409 | 0.77 | SIGMAR1 (0.55) | GAATSHRMEN1KMT2ASIGMAR1 | |
| SCHEMBL15985246 | 0.75 | CYP2D6 (0.60) | GAATSHRMEN1KMT2ASIGMAR1 | |
| SCHEMBL11707747 | 0.75 | GAA (0.61) | GAATSHRMEN1KMT2ASIGMAR1 | |
| SCHEMBL20411117 | 0.74 | GAA (0.46) | GAATSHRMEN1KMT2AFUCA1 | |
| SCHEMBL20402656 | 0.74 | GAA (0.46) | GAATSHRMEN1KMT2AFUCA1 | |
| SCHEMBL20411087 | 0.74 | GAA (0.46) | GAATSHRMEN1KMT2AFUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1192154-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076999-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |