Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 11/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620819 | 0.91 | GRIN2B (0.43) | GRIN2BGRIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL6990992 | 0.90 | GRIN2B (0.59) | GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL6620971 | 0.88 | HRH1 (0.41) | GRIN2BGRIN1ALDH1A1KDM4EGAA | |
| SCHEMBL6316829 | 0.87 | GRIN1 (0.38) | GRIN2BGRIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL6316782 | 0.87 | GRIN1 (0.38) | GRIN2BGRIN1ALDH1A1KDM4EGAA | |
| SCHEMBL6737928 | 0.84 | GRIN2B (0.46) | GRIN2BGRIN1MEN1KMT2AALDH1A1 | |
| SCHEMBL6621946 | 0.82 | MMP12 (0.50) | MEN1ALDH1A1L3MBTL1 | |
| SCHEMBL6316375 | 0.82 | GRIN1 (0.37) | GRIN2BGRIN1ALDH1A1KDM4EGAA | |
| SCHEMBL6325320 | 0.82 | CCR5 (0.37) | GRIN2BGRIN1ALDH1A1KDM4EGAA | |
| SCHEMBL6619543 | 0.81 | MEN1 (0.53) | GRIN2BGRIN1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1047695-B1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| US-6291475-B1 | 3,7-DIAZABICYCLO(3.3.1)NONANE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1047695-A1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | AstraZeneca AB (SE) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999031100-A1 | NOVEL BISPIDINE ANTIARRHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 1999-06-24 | — | — | WO | disclosed |