Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 13/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317335 | 0.95 | MLYCD (0.46) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6317678 | 0.93 | CYP1A2 (0.47) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6317464 | 0.93 | HPGD (0.46) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6316618 | 0.92 | TACR1 (0.46) | TACR1HPGDALDH1A1POLBGAA | |
| SCHEMBL6315919 | 0.90 | CYP1A2 (0.47) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6320981 | 0.90 | HPGD (0.43) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6322892 | 0.89 | DDT (0.46) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6316981 | 0.89 | CYP1A2 (0.44) | CYP1A2CYP2C19SLC9A1HPGDKMT2A | |
| SCHEMBL6317377 | 0.89 | LMNA (0.48) | CYP1A2CYP2C19HPGDKMT2AMEN1 | |
| SCHEMBL6324730 | 0.89 | HPGD (0.46) | CYP1A2CYP2C19SLC9A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | TACR1 4879/4885CYP1A2 4402/4885CYP2C19 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.