SCHEMBL6318394

SCHEMBL6318394

O=S(=O)(c1ccc(O)cc1)c1ccc(-c2ccc(S(=O)(=O)c3ccc(Cl)cc3)cc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.67
MAPK1 P28482 2/20 0.67
CYP3A4 P08684 1/20 0.67
POLB P06746 1/20 0.58
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
GAA P10253 2/20 0.50
KDM4E B2RXH2 2/20 0.50
PKM P14618 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
HSD17B10 Q99714 1/20 0.50
LMNA P02545 1/20 0.46
ESR1 P03372 1/20 0.46
ESR2 Q92731 1/20 0.46
CA1 P00915 4/20 0.45
CA2 P00918 4/20 0.45
MMP2 P08253 2/20 0.45
MMP8 P22894 2/20 0.45
MMP1 P03956 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL720002 1.00 ALDH1A1 (0.67) ALDH1A1MAPK1CYP3A4POLBMEN1
SCHEMBL421528 0.94 ALDH1A1 (0.76) ALDH1A1MAPK1CYP3A4POLBMEN1
SCHEMBL19130271 0.89 GAA (0.54) ALDH1A1MAPK1CYP3A4POLBMEN1
SCHEMBL811489 0.89 GAA (0.59) ALDH1A1MAPK1CYP3A4GAAPKM
SCHEMBL3235446 0.89 GAA (0.59) ALDH1A1MAPK1CYP3A4GAAPKM
SCHEMBL5311344 0.89 GAA (0.59) ALDH1A1MAPK1CYP3A4GAAPKM
SCHEMBL10395680 0.89 GAA (0.59) ALDH1A1MAPK1CYP3A4GAAPKM
SCHEMBL811302 0.89 GAA (0.59) ALDH1A1MAPK1CYP3A4GAAPKM
SCHEMBL11590997 0.89 ALDH1A1 (0.84) ALDH1A1MAPK1CYP3A4POLBMEN1
SCHEMBL1024710 0.89 ALDH1A1 (0.84) ALDH1A1MAPK1CYP3A4POLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4176222-A BY HEATING A BISPHENOL, DIHALOBENZENOID COMPOUND WITH SODIUM CARBONATE OR BICARBONATE AND A SECOND ALKALI METAL CARBONATE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-11-27 US claimed
US-4113699-A POLYETHER KETONES FROM HALOPHENOLS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1978-09-12 US claimed
US-20050107571-A1 Method for producing aromatic polyether SUMITOMO CHEMICAL COMPANY, LIMITED 2005-05-19 US disclosed
US-5395914-A Nucleophilic polycondensation of hydroxy halogen xanthones HOECHST AKTIENGESELLSCHAFT (DE) 1995-03-07 US disclosed
EP-0571883-A1 Polyarylethers with xanthone units, method for their production and their application HOECHST AKTIENGESELLSCHAFT (DE) 1993-12-01 EP disclosed
EP-0222536-B1 AROMATIC POLYMER AND PROCESS FOR ITS PREPARATION IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-01-20 EP disclosed
EP-0182648-B1 PROCESS FOR THE PREPARATION OF POLYETHERKETONES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-08-12 EP disclosed
US-5051495-A Reaction of dialcohol, dithiols with aromatic halogen compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-09-24 US disclosed
US-4950729-A AROMATIC POLYETHERS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-08-21 US disclosed
EP-0292211-A2 Production and/or handling of polymers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-11-23 EP disclosed
US-4711945-A Polyketone IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-12-08 US disclosed
EP-0222536-A2 Aromatic polymer and process for its preparation IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-05-20 EP disclosed
EP-0182648-A2 Process for the Preparation of Polyetherketones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-05-28 EP disclosed
US-4331798-A Production of aromatic polyethers with infusible particulate substance IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-05-25 US disclosed
EP-0010868-A2 Production of aromatic polyethers IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-05-14 EP disclosed
US-4176222-A BY HEATING A BISPHENOL, DIHALOBENZENOID COMPOUND WITH SODIUM CARBONATE OR BICARBONATE AND A SECOND ALKALI METAL CARBONATE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-11-27 US disclosed
US-4169178-A A BISPHENOL OR -DIPHENYL ETHER, SULFIDE, SULFONE, OR KETONE AND A DIHALOBENZENOID COMPOUND AND/OR AN O- OR P-SULFONE- OR KETO-ACTIVATED HALOPHENOL WITH AN ALKALI METAL CARBONATE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-09-25 US disclosed
US-4113699-A POLYETHER KETONES FROM HALOPHENOLS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1978-09-12 US disclosed
US-4105636-A BOILING ORGANIC SULPHOXIDE OR SULPHONE SOLVENT CONTAINING MIXTURE OF BISPHENOL AND AN AROMATIC DIHALO COMPOUND OR A HALOPHENOL AND AN ALKALI CARBONATE IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1978-08-08 US disclosed