Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.49 |
| ▸ | GGT1 | P19440 | 1/20 | 0.43 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63144 | 1.00 | NOS2 (0.49) | NOS2GGT1ARG1ARG2BLM | |
| SCHEMBL63003 | 1.00 | NOS2 (0.49) | NOS2GGT1ARG1ARG2BLM | |
| SCHEMBL11740166 | 0.81 | NOS2 (0.49) | NOS2GGT1ARG1ARG2BLM | |
| Sulfuric Acid SCHEMBL29720683 | 0.76 | NOS2 (0.44) | NOS2GGT1ARG1ARG2BLM | |
| SCHEMBL6555692 | 0.75 | ELANE (0.37) | NOS2ALDH1A1ADRA1ATSHRCYP2D6 | |
| SCHEMBL3904807 | 0.74 | TDP1 (0.32) | NOS2TDP1 | |
| SCHEMBL1835534 | 0.74 | — | — | |
| SCHEMBL366571 | 0.74 | — | — | |
| Methane SCHEMBL8556905 | 0.73 | ALDH1A1 (0.33) | NOS2BLMALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL9987195 | 0.73 | ALDH1A1 (0.33) | NOS2BLMALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276757-B1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2016-01-06 | — | — | EP | disclosed |
| US-20150210718-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIV FLORIDA (US) | 2015-07-30 | — | — | US | disclosed |
| US-9023875-B2 | Macrocyclic compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-9023875-B2 | Macrocyclic compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-9023875-B2 | Macrocyclic compounds and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-8759512-B2 | Methods of preparation of macrocyclic compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759512-B2 | Methods of preparation of macrocyclic compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20110118323-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2011-04-21 | — | — | US | disclosed |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2011-04-21 | — | — | US | disclosed |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2011-04-21 | — | — | US | disclosed |
| EP-2276757-A2 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | University of Florida Research Foundation, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| EP-2190449-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | University of Florida Research Foundation, Inc. (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009126315-A2 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009105284-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009032352-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2009-03-12 | — | — | WO | disclosed |
| US-4302593-A | RECOVERING THE AMINO ACID FROM THE COMPOUND AS A MEANS OF SEPARATION OR PURIFICATION FROM SOLUTION | LOWE ORVILLE G | 1981-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118323-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | NOS2 1476/4885GGT1 1483/4885ARG1 831/4885 |
| US-20110092697-A1 | METHODS OF PREPARATION OF MACROCYCLIC COMPOUNDS | MKI67, CCNC, PCNA | NOS2 677/4885GGT1 585/4885ARG1 2392/4885 |
| US-20150210718-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | HDAC1, HDAC11, HDAC3 | NOS2 2153/4885GGT1 774/4885ARG1 860/4885 |
| US-20140031400-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT | MKI67, MCL1, MYC | NOS2 1476/4885GGT1 1483/4885ARG1 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.