SCHEMBL6318709

SCHEMBL6318709

[CH2]c1ccc2cc(-c3ccccc3)ccc2c1-c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 5/20 0.58
ESR2 Q92731 5/20 0.58
HSD17B1 P14061 7/20 0.53
HSD17B2 P37059 7/20 0.53
CYP1A2 P05177 3/20 0.53
CYP3A4 P08684 3/20 0.53
CYP2D6 P10635 3/20 0.53
CYP2C9 P11712 3/20 0.53
CYP2B6 P20813 3/20 0.53
CYP2C19 P33261 3/20 0.53
GPR84 Q9NQS5 2/20 0.49
BACE1 P56817 1/20 0.40
PGR P06401 1/20 0.39
NPC1 O15118 1/20 0.38
DHFR P00374 1/20 0.38
GRIN2D O15399 1/20 0.36
GRIN2A Q12879 1/20 0.36
GRIN2B Q13224 1/20 0.36
GRIN2C Q14957 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6310656 0.80 ALDH1A1 (0.46) ESR1ESR2NPC1
SCHEMBL6313330 0.80 GRIN2D (0.49) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL30703158 0.80 ESR1 (0.58) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL2724557 0.80 ESR1 (0.58) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL1987912 0.80 ESR1 (0.58) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL26087283 0.79 ESR1 (0.60) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL4260155 0.78 ESR1 (0.58) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL5426888 0.78 ESR1 (0.90) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL6318714 0.78 ESR1 (0.58) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL3005121 0.78 ESR1 (0.56) ESR1ESR2HSD17B1HSD17B2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6924301-B1 Composition for treating or preventing arrhythmia SHIONOGI & CO., LTD. (JP) 2005-08-02 US disclosed
EP-0976748-B1 PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY SHIONOGI & CO (JP) 2003-12-03 EP disclosed
EP-1240906-A1 PREVENTIVES OR REMEDIES FOR ARRHYTHMIA SHIONOGI & CO., LTD. (JP) 2002-09-18 EP disclosed
US-6147100-A ANTIINFLAMMATORY AGENTS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
EP-0976748-A1 PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY SHIONOGI & CO., LTD. (JP) 2000-02-02 EP disclosed