Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654992 | 0.90 | ALDH1A1 (0.56) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6319889 | 0.87 | ALDH1A1 (0.53) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6311130 | 0.84 | HIF1A (0.57) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6312311 | 0.83 | ALDH1A1 (0.57) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6310374 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| Formic Acid SCHEMBL6313188 | 0.82 | NPSR1 (0.54) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6309879 | 0.82 | MEN1 (0.57) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| Hydrochloric Acid SCHEMBL6311165 | 0.82 | HIF1A (0.55) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6398897 | 0.80 | HIF1A (0.51) | ALDH1A1HPGDTSHRCASP1CASP7 | |
| SCHEMBL6314338 | 0.80 | HIF1A (0.56) | ALDH1A1HPGDTSHRCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143578-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2005-06-30 | — | — | US | disclosed |
| US-20040192914-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192914-A1 | Compounds and methods | METAP2, METAP1, DNPEP | ALDH1A1 677/4885HPGD 1227/4885TSHR 2272/4885 |
| US-20050143578-A1 | Compounds and methods | METAP2, METAP1, DNPEP | ALDH1A1 977/4885HPGD 1186/4885TSHR 2470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.