Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.51 |
| ▸ | PDE2A | O00408 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6318859 | 0.89 | PDE3B (0.62) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL29832159 | 0.79 | PDE5A (0.65) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL6068421 | 0.79 | PDE5A (0.65) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL3997507 | 0.73 | ADRA1D (0.44) | KDM4EMAPTALDH1A1PDE5ALMNA | |
| SCHEMBL6324483 | 0.72 | PDE3B (0.74) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL6317100 | 0.72 | PDE3B (0.55) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL6068359 | 0.71 | PDE5A (0.64) | KDM4EMAPTALDH1A1PDE5ALMNA | |
| SCHEMBL6323630 | 0.70 | PDE3B (0.73) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL6317718 | 0.70 | PDE3B (0.67) | PDE3BPDE3APDE2AKDM4EMAPT | |
| SCHEMBL6325710 | 0.70 | PDE3B (0.73) | PDE3BPDE3APDE2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | claimed |
| US-6838559-B2 | Purine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2005-01-04 | — | — | US | disclosed |