Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300054 | 0.82 | PDE5A (0.52) | ADRA1DADRA1AADRA1BPDE5AALDH1A1 | |
| SCHEMBL6318859 | 0.74 | PDE3B (0.62) | PDE5AALDH1A1MAPTGAALMNA | |
| SCHEMBL6319710 | 0.73 | PDE3B (0.51) | PDE5AALDH1A1MAPTGAALMNA | |
| SCHEMBL3998907 | 0.73 | ABCG2 (0.50) | ALDH1A1TSHRMAPTLMNAHIF1A | |
| SCHEMBL3997921 | 0.73 | ABCG2 (0.64) | ALDH1A1TSHRKMT2AMEN1HPGD | |
| Formic Acid SCHEMBL4761941 | 0.73 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BPDE5AALDH1A1 | |
| SCHEMBL29832159 | 0.72 | PDE5A (0.65) | PDE5AALDH1A1MAPTGAALMNA | |
| SCHEMBL6068421 | 0.72 | PDE5A (0.65) | PDE5AALDH1A1MAPTGAALMNA | |
| SCHEMBL299899 | 0.71 | PDE5A (0.47) | PDE5AALDH1A1TSHRMAPTLMNA | |
| SCHEMBL9132869 | 0.71 | SMN1; SMN2 (0.69) | ADRA1DADRA1AADRA1BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601836-B2 | Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-13 | — | — | US | disclosed |
| US-20060116516-A1 | Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7 | PITTS WILLIAM J | 2006-06-01 | — | — | US | disclosed |
| US-7022849-B2 | Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7 | BRISTOL-MYERS SQUIBB CO. (US) | 2006-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116516-A1 | Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7 | PDE3A, PDE3B, PDE2A | ADRA1D 400/4885ADRA1A 1236/4885ADRA1B 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.