Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320099 | 1.00 | POLB (0.41) | POLBPKMIDO1TDO2KMT2A | |
| SCHEMBL6320790 | 0.87 | ALDH1A1 (0.49) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6320785 | 0.87 | ALDH1A1 (0.49) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6328129 | 0.87 | PTPN1 (0.49) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6328124 | 0.87 | PTPN1 (0.49) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6318812 | 0.86 | RAB9A (0.52) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6318809 | 0.86 | RAB9A (0.52) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6320651 | 0.86 | IDO1 (0.39) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6320644 | 0.86 | IDO1 (0.39) | POLBIDO1TDO2KMT2AMEN1 | |
| SCHEMBL6328078 | 0.86 | MAPK10 (0.40) | POLBIDO1TDO2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |