Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | MDM4 | O15151 | 4/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12189642 | 0.82 | NPC1 (0.69) | TP53HTTLMNANPC1GAA | |
| SCHEMBL7154697 | 0.78 | MDM4 (0.66) | TP53MDM4MDM2NPC1CYP1A2 | |
| SCHEMBL4915684 | 0.78 | TP53 (0.61) | TP53MDM4MDM2HTTLMNA | |
| SCHEMBL14890169 | 0.77 | CYP1A2 (0.74) | TP53MDM4MDM2LMNAHPGD | |
| SCHEMBL6120684 | 0.76 | ALDH1A1 (0.61) | TP53HTTLMNANPC1GAA | |
| SCHEMBL4923542 | 0.74 | TP53 (0.56) | TP53MDM4MDM2HTTLMNA | |
| SCHEMBL28592851 | 0.74 | TDP1 (0.57) | HTTLMNANPC1GAAALDH1A1 | |
| SCHEMBL434287 | 0.74 | NPC1 (0.59) | TP53HTTLMNANPC1GAA | |
| SCHEMBL24093864 | 0.74 | MAPT (0.50) | TP53HTTLMNAGAAHPGD | |
| SCHEMBL26066184 | 0.74 | SMN1; SMN2 (0.57) | TP53LMNAGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |