SCHEMBL7154697

SCHEMBL7154697

O=C(O)c1ccccc1C(=O)Nc1ccccc1S

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MDM4 O15151 3/20 0.66
TP53 P04637 3/20 0.66
KMT2A Q03164 5/20 0.59
ALDH1A1 P00352 2/20 0.59
MAPT P10636 2/20 0.57
HDAC8 Q9BY41 1/20 0.57
MDM2 Q00987 1/20 0.54
MEN1 O00255 3/20 0.51
PKM P14618 2/20 0.51
POLB P06746 1/20 0.51
PRNP P04156 1/20 0.51
PPARG P37231 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
NCOR2 Q9Y618 1/20 0.51
KDM4E B2RXH2 2/20 0.50
ALOX15 P16050 1/20 0.50
GRIK1 P39086 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
DHODH Q02127 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4915684 0.86 TP53 (0.61) MDM4TP53KMT2AALDH1A1HDAC8
SCHEMBL2058331 0.85 ALDH1A1 (0.68) TP53KMT2AALDH1A1MEN1PKM
SCHEMBL14890169 0.81 CYP1A2 (0.74) MDM4TP53ALDH1A1MAPTMDM2
SCHEMBL28965115 0.80 LMNA (0.76) TP53KMT2AALDH1A1MAPTMEN1
SCHEMBL13927141 0.80 HSD17B10 (0.61) TP53KMT2AALDH1A1MEN1PKM
SCHEMBL333488 0.79 MDM4 (1.00) MDM4TP53KMT2AMAPTMDM2
SCHEMBL14398138 0.79 NPSR1 (0.68) KMT2AALDH1A1MEN1PKMPOLB
SCHEMBL4487883 0.79 HDAC1 (0.66) KMT2AALDH1A1HDAC8MEN1PKM
SCHEMBL2700280 0.79 CYP1A2 (0.77) KMT2AALDH1A1MAPTPOLBKDM4E
SCHEMBL11284668 0.79 PDCD1 (0.64) KMT2AALDH1A1MAPTMEN1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6534659-B2 Amidation of an acid anhydride by a compound comprising a nitrogen/sulfur saturated ring, e.g., thiazolidine; odorless corrosion inhibitors for metal; pollution control NIPPON SHOKUBAI CO., LTD. (JP) 2003-03-18 US disclosed
US-20010047096-A1 Amidation of an acid anhydride by a compound comprising a nitrogen/sulfur saturated ring, e.g., thiazolidine; odorless corrosion inhibitors for metal; pollution control NIPPON SHOKUBAI CO., LTD. (JP) 2001-11-29 US disclosed
EP-1149833-A1 Sulfidoamidocarboxylic acids used as corrosion inhibitors Nippon Shokubai Co., Ltd. (JP) 2001-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010047096-A1 Amidation of an acid anhydride by a compound comprising a nitrogen/sulfur saturated ring, e.g., thiazolidine; odorless corrosion inhibitors for metal; pollution control CTH, TST, SLC7A11 MDM4 579/4885TP53 2377/4885KMT2A 1498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.