Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.48 |
| ▸ | BCHE | P06276 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358026 | 0.91 | LMNA (0.54) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL31465578 | 0.91 | LMNA (0.54) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL3926186 | 0.77 | LMNA (0.56) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL14549026 | 0.76 | AR (0.58) | ALDH1A1HDAC4HDAC8 | |
| SCHEMBL16953409 | 0.76 | ACHE (0.37) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL19122398 | 0.76 | ACHE (0.37) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL10361169 | 0.76 | ACHE (0.40) | ACHE | |
| SCHEMBL14200357 | 0.75 | ACHE (0.55) | ACHEBCHEHTTSMN1; SMN2LMNA | |
| SCHEMBL801219 | 0.75 | HDAC4 (0.48) | ACHEBCHESMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14200361 | 0.75 | LMNA (0.58) | ACHEBCHEHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |
| EP-1211253-A1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-05 | — | — | EP | disclosed |