Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325218 | 0.90 | MAPT (0.53) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6324750 | 0.90 | TSHR (0.57) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6334966 | 0.86 | MAPT (0.53) | HPGDTSHRMAPTSMN1; SMN2LMNA | |
| SCHEMBL6323935 | 0.83 | MAPT (0.52) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6328013 | 0.82 | TSHR (0.57) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6323563 | 0.79 | TSHR (0.57) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6324626 | 0.78 | DNMT3B (0.57) | HPGDTSHRMAPTGAALMNA | |
| SCHEMBL6328474 | 0.78 | GAA (0.57) | HPGDTSHRMAPTSMN1; SMN2GAA | |
| SCHEMBL6328082 | 0.77 | DNMT3B (0.52) | HPGDTSHRMAPTGAALMNA | |
| SCHEMBL6333150 | 0.76 | TP53 (0.50) | HPGDTSHRMAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |