Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790236 | 0.83 | ALOX15 (0.39) | IDO1ALOX15SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13614185 | 0.80 | GAA (0.41) | ALOX15SMN1; SMN2ALDH1A1MAPTGFER | |
| SCHEMBL13958922 | 0.80 | ALDH1A1 (0.39) | ALOX15SMN1; SMN2ALDH1A1MAPTGFER | |
| SCHEMBL11123121 | 0.77 | ALOX15 (0.43) | IDO1ALOX15SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18901018 | 0.77 | DPP4 (0.44) | IDO1ALOX15SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28583866 | 0.77 | ALOX15 (0.43) | IDO1ALOX15SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL28861332 | 0.77 | ALOX15 (0.43) | IDO1ALOX15SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5381933 | 0.76 | KDM4E (0.49) | ALOX15SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL2219196 | 0.75 | MEN1 (0.51) | ALOX15SMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL18095847 | 0.74 | HRH4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | IDO1 855/4885THRB 2605/4885ALOX15 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.